Tirzepatide has the bigger number: 20.2% against 13.7%, in one open-label, Lilly-funded trial. Semaglutide has the bigger trial: 17,604 people and a fifth fewer heart attacks and strokes. Which matters depends on what you are trying to lose.
Muscle growth was the same at light and heavy loads across 28 trials, as long as sets went near failure. Push-ups matched a bench press in three more. The catch is not the equipment. It is where bodyweight runs out of ways to get harder.
Cut sugar and eat freely, and the trials show about 1.8 lb gone. Swap it for the same calories of other carbs and the scale does not move. What a no-sugar diet actually is, and why the detox has nothing to detox.
In 114 trials, people who lifted and changed nothing about their diet lost fat and gained muscle at the same time. The hard part is not the recomp. It is the deficit you chose to hurry it.
The calorie number on the thumbnail is about triple what was measured, and the trials came up short on fat. So why does anyone lose weight dancing? We think the answer is a calendar, not a calorie table.
The number on the display has a decimal place. The research says a single reading is compatible with a real value across a 23-point span, and that the scale gets your change right about a quarter of the time.
The largest review ever done on it says exercise helps chronic back pain, with moderate certainty. The same body of research says something very different about a new episode — and almost nothing about which exercise.
Slowing the rep down is sold as the secret to growth. A 2025 meta-analysis of every study that varied only tempo found the difference was 0.09 — and it leaned the other way.
A new randomised trial measured thigh muscle by MRI before and after. The loss is real, lifting halved it, and the number that actually moved was protein.
One of the few things in the supplement aisle with an umbrella review behind it. Here is the dose, the timing, the size of the effect — and the one thing it is not doing.